Article

Both T and B cells contribute to dysregulated activation and differentiation of CD4 <sup>+</sup> T cells in Activated PI3K delta syndrome 1

2024-08-04

Abstract excerpt

Activated PI3K delta syndrome 1 (APDS1) is caused by a heterozygous germline gain-of-function (GOF) variants in PIK3CD which encodes the p110δ catalytic subunit of phosphoinositide 3-kinase (PI3K). APDS1 patients display a broad range of clinical manifestations and perturbations in cellular phenotype. One of the most striking features is the dysregulation of the T cell compartment characterised by an increase in...

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Literature Corpus work: 984a96bb-54b9-5a48-946c-4913a98400b3
DOI: 10.1101/2024.08.04.606503

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