Article

Profilin 1 maintains cell cycle fidelity to prevent unscheduled genome doubling and polyploidy in cancer

2026-05-15

Abstract excerpt

Whole-genome doubling (WGD) represents a major route to genome instability and therapeutic resistance in cancer; yet, the mechanisms enabling genome duplication in p53-proficient cells remain poorly understood. Here, we identify Profilin 1 ( PFN1 ) loss as a driver of WGD through impaired mitotic entry. Using FUCCI live-cell imaging and single-cell genomic profiling, we show that PFN1-deficient cells bypass mitos...

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Literature Corpus work: 4b937d0e-fa11-5485-b4b3-d65683d71d4f
DOI: 10.64898/2026.05.12.724607

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