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Somatic Cell Fusions Reveal Extensive Heterogeneity in Basal-like Breast Cancer

1 Jun 2015

Abstract excerpt

Basal-like and luminal breast tumors have distinct clinical behavior and molecular profiles, yet the underlying mechanisms are poorly defined. To interrogate processes that determine these distinct phenotypes and their inheritance pattern, we generated somatic cell fusions and performed integrated genetic and epigenetic (DNA methylation and chromatin) profiling. We found that the basal-like trait is generally...

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PMID: 26051943
DOI: 10.1016/j.celrep.2015.05.011

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