Article

Cis-regulatory architecture of human ESC-derived hypothalamic neuron differentiation aids in variant-to-gene mapping of relevant complex traits

2020-07-06

Abstract excerpt

<h4>Summary</h4> The hypothalamus regulates metabolic homeostasis by influencing behavior, energy utilization and endocrine systems. Given its role governing health-relevant traits, such as body weight and reproductive timing, understanding the genetic regulation of hypothalamic development and function should yield insights into these traits and diseases. However, given its inaccessibility, studying human hypoth...

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Literature Corpus work: 87e9b16c-5698-506d-a78e-7eaf12d12f30
DOI: 10.1101/2020.07.06.146951

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