Back to search

Article

A D-2-Hydroxyglutarate dehydrogenase mutant reveals a critical role for ketone body metabolism in <i>Caenorhabditis elegans</i> development

2022-05-17

Abstract excerpt

<h4>SUMMARY</h4> In humans, mutations in D-2-hydroxyglutarate (D-2HG) dehydrogenase (D2HGDH) result in D-2HG accumulation, delayed development, seizures, and ataxia. While the mechanisms of 2HG-associated diseases have been studied extensively, the endogenous metabolism of D-2HG remains unclear in any organism. Here, we find that, in Caenorhabditis elegans , D-2HG is produced in the propionate shunt, which is tr...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
d307dd51-a9fe-5314-bfed-5cd51f7f7b0c
DOI
10.1101/2022.05.16.492161
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
A D-2-Hydroxyglutarate dehydrogenase mutant reveals a critical role for ketone body metabolism in <i>Caenorhabditis elegans</i> developmentDOI 10.1101/2022.05.16.492161
A D-2-hydroxyglutarate dehydrogenase mutant reveals a critical role for ketone body metabolism in Caenorhabditis elegans developmentSemantic proximity
idh-1 neomorphic mutation confers sensitivity to vitamin B12 in Caenorhabditis elegans.Semantic proximity
2-Hydroxyglutarate Inhibits ATP Synthase and mTOR Signaling.Semantic proximity
New alleles of D-2-hydroxyglutarate dehydrogenase enable studies of oncometabolite function in Drosophila melanogaster.Semantic proximity
<i> ndufs2 <sup>-/-</sup> </i> zebrafish have impaired survival, neuromuscular activity, morphology, and one-carbon metabolism treatable with folic acidSemantic proximity
Dichloroacetate improves animal survival, growth, neuromuscular activity, mitochondrial stress and physiology, and elevated lactate in <i>C. elegans pdha-1</i> and <i>dld-1</i> RNAi models of pyruvate dehydrogenase complex deficiency (PDCD)Semantic proximity
Natural variation in a glucuronosyltransferase modulates propionate sensitivity in a <i>C. elegans</i> propionic acidemia modelSemantic proximity
New alleles of <i>D-2-hydroxyglutarate dehydrogenase</i> enable studies of oncometabolite function in <i>Drosophila melanogaster</i>Semantic proximity
A Drosophila model of combined D-2- and L-2-hydroxyglutaric aciduria reveals a mechanism linking mitochondrial citrate export with oncometabolite accumulation.Semantic proximity
The SDHB Arg230His mutation causing familial paraganglioma alters glycolysis in a new Caenorhabditis elegans model.Semantic proximity
Biochemistry, function, and deficiency of vitamin B <sub>12</sub> in <i>Caenorhabditis elegans</i>Semantic proximity
Spatial Partitioning of Glucose Metabolism Supports Tissue-Specific Metabolic Programs In VivoSemantic proximity
Select a neighboring publication to make it the new centre.