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Islet amyloid polypeptide tagged with green fluorescent protein localises to mitochondria and forms filamentous aggregates in <i>Caenorhabditis elegans</i>

2023-10-27

Abstract excerpt

Type 2 diabetes (T2D) is the most common form of diabetes and represents a growing health concern. A characteristic feature of T2D is the aggregation of islet amyloid polypeptide (IAPP), which is thought to be associated with the death of pancreatic β-cells. Inhibiting IAPP aggregation is a promising therapeutic avenue to treat T2D, but the mechanisms of aggregation and toxicity are not yet fully understood. Caen...

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Literature Corpus work
7de0acee-a238-5e9d-84ef-d978f9bcfdf8
DOI
10.1101/2023.10.27.564377
Open publication

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Islet amyloid polypeptide tagged with green fluorescent protein localises to mitochondria and forms filamentous aggregates in <i>Caenorhabditis elegans</i>DOI 10.1101/2023.10.27.564377
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