Article
Fragile lifespan expansion by dietary mitohormesis in C. elegans.
Aging - 1 Jan 2016
Tauffenberger Arnaud, Vaccaro Alexandra, Parker J Alex
Abstract excerpt
Mitochondrial function is central to longevity and an imbalance in mitonuclear protein homeostasis activates a protective response called the mitochondrial unfolded protein response (UPRmt). Toxic compounds damaging mitochondria trigger the UPRmt, but at sublethal doses these insults extend lifespan in simple animals like C. elegans. Mitochondria are the main energy suppliers in eukaryotes, but it is not known if...
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