Article

Fasting prevents hypoxia-induced defects of proteostasis in <i>C. elegans</i>

2018-03-08

Abstract excerpt

Low oxygen conditions (hypoxia) can impair essential physiological processes and cause cellular damage and death. We have shown that specific hypoxic conditions disrupt protein homeostasis in C. elegans , leading to protein aggregation and proteotoxicity. Here, we show that nutritional cues regulate this effect of hypoxia on proteostasis. Animals fasted prior to hypoxic exposure develop dramatically fewer protein...

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Literature Corpus work: dd49ccbc-39f9-5943-8582-3ae7577d8f66
DOI: 10.1101/278671

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