Article

Rapid discovery of synthetic DNA sequences to rewrite endogenous T cell circuits

2019-04-12

Abstract excerpt

<h4>ABSTRACT</h4> Genetically-engineered immune cell therapies have been in development for decades 1–3 and recently have proven effective to treat some types of cancer 4 . CRISPR-based genome editing methods, enabling more flexible and targeted sequence integrations than viral transduction, have the potential to extend the clinical utility of cell therapies 5,6 . Realization of this potential depends on impro...

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Literature Corpus work: 191a6c18-e4fa-57bd-a2eb-3a5248e2a733
DOI: 10.1101/604561

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