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Programming gene and engineered-cell therapies with synthetic biology

9 Feb 2018

Abstract excerpt

Gene and engineered-cell therapies promise to treat diseases by genetically modifying cells to carry out therapeutic tasks. Although the field has had some success in treating monogenic disorders and hematological malignancies, current approaches are limited to overexpression of one or a few transgenes, constraining the diseases that can be treated with this approach and leading to potential concerns over safety...

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PMID: 29439214
DOI: 10.1126/science.aad1067

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