Article

The histone variant macroH2A1.1 regulates RNA Polymerase II paused genes within defined chromatin interaction landscapes

2020-01-29

Abstract excerpt

The histone variant macroH2A1.1 (mH2A1.1) plays a role in cancer development and metastasis-related processes. To determine the underlying molecular mechanisms, we mapped genome-wide localization of endogenous mH2A1.1 in the human breast cancer cell MDA-MB 231. We demonstrate that mH2A1.1 specifically binds to active promoters and enhancers in addition to facultative heterochromatin. Selective knock-down of mH2A1....

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 6c224021-1a8a-5a61-ad1c-2e1df0ea2536
DOI: 10.1101/2020.01.29.924704

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

The histone variant macroH2A1.1 regulates RNA Polymerase II paused genes within defined chromatin interaction landscapesDOI 10.1101/2020.01.29.924704Read

Repurposed macroH2A Chromatin Landscapes Guide Cellular ReprogrammingSemantic proximity Read

FACT mediates the depletion of macroH2A1.2 to expedite gene transcription.Semantic proximity Read

The Histone Variant MacroH2A Blocks Cellular Reprogramming by Inhibiting Mesenchymal-to-Epithelial Transition.Semantic proximity Read

Histone MacroH2A1: A Chromatin Point of Intersection between Fasting, Senescence and Cellular RegenerationSemantic proximity Read

Human macroH2A1 drives nucleosome dephasing and genome instability in histone-humanized yeastSemantic proximity Read

macroH2A1 histone variants are depleted on active genes but concentrated on the inactive X chromosome.Semantic proximity Read

Systematic identification of chromatin organizers as tuners of intratumoral heterogeneitySemantic proximity Read

The Atypical Histone MacroH2A1.2 Interacts with HER-2 Protein in Cancer CellsSemantic proximity Read

macroH2A2 antagonizes epigenetic programs of stemness in glioblastomaSemantic proximity Read

MacroH2A restricts inflammatory gene expression in melanoma cancer-associated fibroblasts by coordinating chromatin loopingSemantic proximity Read

macroH2A2 shapes chromatin accessibility at enhancer elements in glioblastoma to modulate a targetable self-renewal epigenetic networkSemantic proximity Read

Re-Targeting of Macroh2A Following Mitosis to Cytogenetic-Scale Heterochromatic DomainsSemantic proximity Read