Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

MacroH2A restricts inflammatory gene expression in melanoma cancer-associated fibroblasts by coordinating chromatin looping

21 Aug 2023

Abstract excerpt

MacroH2A has established tumour suppressive functions in melanoma and other cancers, but an unappreciated role in the tumour microenvironment. Using an autochthonous, immunocompetent mouse model of melanoma, we demonstrate that mice devoid of macroH2A variants exhibit increased tumour burden compared with wild-type counterparts. MacroH2A-deficient tumours accumulate immunosuppressive monocytes and are depleted of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer Immunotherapy and Biomarkers
Share to Epigenetics and DNA Methylation
Share to Immunotherapy and Immune Responses

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 37605008
DOI: 10.1038/s41556-023-01208-7

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

MacroH2A restricts inflammatory gene expression in melanoma cancer-associated fibroblasts by coordinating chromatin loopingPMID 37605008Read ↗

MacroH2A impedes metastatic growth by enforcing a discrete dormancy program in disseminated cancer cellsSemantic proximity Read ↗

MacroH2A impedes metastatic growth by enforcing a discrete dormancy program in disseminated cancer cellsSemantic proximity Read ↗

macroH2A2 antagonizes epigenetic programs of stemness in glioblastomaSemantic proximity Read ↗

Reprogramming of bivalent chromatin states in NRAS mutant melanoma suggests PRC2 inhibition as a therapeutic strategy.Semantic proximity Read ↗

The epigenetic modifier EZH2 controls melanoma growth and metastasis through silencing of distinct tumour suppressors.Semantic proximity Read ↗

Mi-2β promotes immune evasion in melanoma by activating EZH2 methylationSemantic proximity Read ↗

EZH2 in Acral Lentiginous Melanoma: Molecular, Epigenetic, and Therapeutic Perspectives.Semantic proximity Read ↗

FACT mediates the depletion of macroH2A1.2 to expedite gene transcription.Semantic proximity Read ↗

Geometric regulation of histone state directs melanoma reprogrammingSemantic proximity Read ↗

Geometric regulation of histone state directs melanoma reprogrammingSemantic proximity Read ↗

Histone MacroH2A1: A Chromatin Point of Intersection between Fasting, Senescence and Cellular RegenerationSemantic proximity Read ↗

ZEB1 controls a lineage-specific transcriptional program essential for melanoma cell state transitionsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.