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Article

FACT mediates the depletion of macroH2A1.2 to expedite gene transcription.

Molecular cell - 22 Aug 2024

Ji Dengyu, Xiao Xue, Luo Anfeng, Fan Xiongxiong, Ma Jingzhe, Wang Dayi, Xia Miaoran, Ma Lu, Wang Peng-Ye, Li Wei, Chen Ping

Abstract excerpt

The histone variant macroH2A is generally linked to transcriptionally inactive chromatin, but how macroH2A regulates chromatin structure and functions in the transcriptional process remains elusive. This study reveals that while the integration of human macroH2A1.2 into nucleosomes does not affect their stability or folding dynamics, it notably hinders the maintenance of facilitates chromatin transcription's...

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PMID: 39116874
DOI: 10.1016/j.molcel.2024.07.011

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