Article

macroH2A2 shapes chromatin accessibility at enhancer elements in glioblastoma to modulate a targetable self-renewal epigenetic network

2021-02-23

Abstract excerpt

<h4>SUMMARY</h4> Self-renewal is a crucial property of glioblastoma cells and is enabled by the choreographed function of chromatin regulators and transcription factors. Identifying targetable epigenetic mechanisms of self-renewal could represent an important step toward developing new and effective treatments for this universally lethal cancer. Here we uncover a targetable epigenetic axis of self-renewal mediate...

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Literature Corpus work: 81e9d598-5825-5782-a28c-e4643fa4c7d6
DOI: 10.1101/2021.02.23.432465

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