Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The Atypical Histone MacroH2A1.2 Interacts with HER-2 Protein in Cancer Cells

16 May 2012

Abstract excerpt

Because HER-2 has been demonstrated in the nuclei of cancer cells, we hypothesized that it might interact with transcription factors that activate ERBB2 transcription. Macrohistone 2A1 ( H2AFY ; mH2A1) was found to interact with HER-2 in cancer cells that overexpress HER-2. Of the two human mH2A1 isoforms, mH2A1.2, but not mH2A1.1, interacted with HER-2 in human cancer cell lines. Overexpression of mH2A1.2, but...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer-related gene regulation
Share to Genomics and Chromatin Dynamics
Share to HER2/EGFR in Cancer Research

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 22589551
DOI: 10.1074/jbc.m112.379412

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The Atypical Histone MacroH2A1.2 Interacts with HER-2 Protein in Cancer CellsPMID 22589551Read ↗

The histone variant macroH2A1.1 regulates RNA Polymerase II paused genes within defined chromatin interaction landscapesSemantic proximity Read ↗

macroH2A2 antagonizes epigenetic programs of stemness in glioblastomaSemantic proximity Read ↗

macroH2A2 shapes chromatin accessibility at enhancer elements in glioblastoma to modulate a targetable self-renewal epigenetic networkSemantic proximity Read ↗

FACT mediates the depletion of macroH2A1.2 to expedite gene transcription.Semantic proximity Read ↗

Histone Variant MacroH2A1 Plays an Isoform-Specific Role in Suppressing Epithelial-Mesenchymal TransitionSemantic proximity Read ↗

Skp2–MacroH2A1–CDK8 axis orchestrates G2/M transition and tumorigenesisSemantic proximity Read ↗

Histone variant MacroH2A1 is downregulated in prostate cancer and influences malignant cell phenotypeSemantic proximity Read ↗

The histone H2A variant macroH2A1 does not localize to the centrosome.Semantic proximity Read ↗

Incorporating histone H2B variants into chromatin modifies chromatin accessibility to induce epithelial-to-mesenchymal transition in breast cancerSemantic proximity Read ↗

Histone H2A variants and the inactive X chromosome: identification of a second macroH2A variant.Semantic proximity Read ↗

Induction of cancer cell stemness by depletion of macrohistone H2A1 in hepatocellular carcinomaSemantic proximity Read ↗

MacroH2A impedes metastatic growth by enforcing a discrete dormancy program in disseminated cancer cellsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.