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Article

The Histone Variant MacroH2A Blocks Cellular Reprogramming by Inhibiting Mesenchymal-to-Epithelial Transition.

Molecular and cellular biology - 15 May 2018

Pliatska Maria, Kapasa Maria, Kokkalis Antonis, Polyzos Alexander, Thanos Dimitris

Abstract excerpt

Transcription factor-induced reprogramming of somatic cells to pluripotency is mediated via profound alterations in the epigenetic landscape. The histone variant macroH2A1 (mH2A1) is a barrier to the cellular reprogramming process. We demonstrate here that mH2A1 blocks reprogramming and contributes to the preservation of cell identity by trapping cells at the very early stages of the process, namely, at the...

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PMID: 29483300
DOI: 10.1128/MCB.00669-17
PMCID: PMC5954199

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MET

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