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Article

macroH2A1 histone variants are depleted on active genes but concentrated on the inactive X chromosome.

Molecular and cellular biology - 1 Jun 2006

Changolkar Lakshmi N, Pehrson John R

Abstract excerpt

Using a novel thiol affinity chromatography approach to purify macroH2A1-containing chromatin fragments, we examined the distribution of macroH2A1 histone variants in mouse liver chromatin. We found that macroH2A1 was depleted on the transcribed regions of active genes. This depletion was observed on all of the 20 active genes that we probed, with only one site showing a small amount of enrichment. In contrast,...

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Identifiers

PMID: 16738309
DOI: 10.1128/MCB.02258-05
PMCID: PMC1489112

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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