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Article

macroH2A2 antagonizes epigenetic programs of stemness in glioblastoma

27 May 2023

Abstract excerpt

Self-renewal is a crucial property of glioblastoma cells that is enabled by the choreographed functions of chromatin regulators and transcription factors. Identifying targetable epigenetic mechanisms of self-renewal could therefore represent an important step toward developing effective treatments for this universally lethal cancer. Here we uncover an epigenetic axis of self-renewal mediated by the histone...

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PMID: 37244935
DOI: 10.1038/s41467-023-38919-2

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