The TREM2-APOE Pathway Drives the Transcriptional Phenotype of Dysfunctional Microglia in Neurodegenerative Diseases.

doi:10.1016/j.immuni.2017.08.008

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Article

The TREM2-APOE Pathway Drives the Transcriptional Phenotype of Dysfunctional Microglia in Neurodegenerative Diseases.

Immunity - 19 Sept 2017

Krasemann Susanne, Madore Charlotte, Cialic Ron, Baufeld Caroline, Calcagno Narghes, El Fatimy Rachid, Beckers Lien, O'Loughlin Elaine, Xu Yang, Fanek Zain, Greco David J, Smith Scott T, Tweet George, Humulock Zachary, Zrzavy Tobias, Conde-Sanroman Patricia, Gacias Mar, Weng Zhiping, Chen Hao, Tjon Emily, Mazaheri Fargol, Hartmann Kristin, Madi Asaf, Ulrich Jason D, Glatzel Markus, Worthmann Anna, Heeren Joerg, Budnik Bogdan, Lemere Cynthia, Ikezu Tsuneya, Heppner Frank L, Litvak Vladimir, Holtzman David M, Lassmann Hans, Weiner Howard L, Ochando Jordi, Haass Christian, Butovsky Oleg

Abstract excerpt

Microglia play a pivotal role in the maintenance of brain homeostasis but lose homeostatic function during neurodegenerative disorders. We identified a specific apolipoprotein E (APOE)-dependent molecular signature in microglia from models of amyotrophic lateral sclerosis (ALS), multiple sclerosis (MS), and Alzheimer's disease (AD) and in microglia surrounding neuritic β-amyloid (Aβ)-plaques in the brains of...

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Identifiers

PMID: 28930663
DOI: 10.1016/j.immuni.2017.08.008
PMCID: PMC5719893

Genes

APOE
TREM2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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