Article

Enrichment in conservative amino acid changes among fixed and standing missense variations in slow evolving proteins

2019-05-21

Abstract excerpt

Proteins were first used in the early 1960s to discover the molecular clock dating method and remain in common usage today in phylogenetic inferences based on neutral variations. To avoid substitution saturation, it is necessary to use slow evolving genes. However, it remains unclear whether fixed and standing missense changes in such genes may qualify as neutral. Here, based on the evolutionary rates as inferred...

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Literature Corpus work: 6bfa1af7-9eb4-5cc3-b041-41e7bd409a10
DOI: 10.1101/644666

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