Different evolutionary patterns of SNPs between domains and unassigned regions in human protein-coding sequences.

doi:10.1007/s00438-016-1170-7

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Article

Different evolutionary patterns of SNPs between domains and unassigned regions in human protein-coding sequences.

Molecular genetics and genomics : MGG - 1 Jun 2016

Pang Erli, Wu Xiaomei, Lin Kui

Abstract excerpt

Protein evolution plays an important role in the evolution of each genome. Because of their functional nature, in general, most of their parts or sites are differently constrained selectively, particularly by purifying selection. Most previous studies on protein evolution considered individual proteins in their entirety or compared protein-coding sequences with non-coding sequences. Less attention has been paid...

Topics

Amino Acid Sequence
Chromosome Mapping
Evolution, Molecular
Gene Frequency
Humans
Open Reading Frames
Polymorphism, Single Nucleotide
Protein Domains
Proteins
Selection, Genetic

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Identifiers

PMID: 26833483
DOI: 10.1007/s00438-016-1170-7
PMCID: PMC4875946

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