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Article

Nonsynonymous substitution rate (Ka) is a relatively consistent parameter for defining fast-evolving and slow-evolving protein-coding genes.

Biology direct - 22 Feb 2011

Wang Dapeng, Liu Fei, Wang Lei, Huang Shi, Yu Jun

Abstract excerpt

BACKGROUND: Mammalian genome sequence data are being acquired in large quantities and at enormous speeds. We now have a tremendous opportunity to better understand which genes are the most variable or conserved, and what their particular functions and evolutionary dynamics are, through comparative genomics. RESULTS: We chose human and eleven other high-coverage mammalian genome data-as well as an avian genome as...

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PMID: 21342519
DOI: 10.1186/1745-6150-6-13
PMCID: PMC3055854

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