Article

The effectiveness of selection in a species affects the direction of amino acid frequency evolution

2023-02-03

Abstract excerpt

Nearly neutral theory predicts that species with higher effective population size ( N e ) are better at purging slightly deleterious mutations. We compare evolution in high- N e vs. low- N e vertebrates to reveal subtle selective preferences among amino acids. We take three complementary approaches. First, we fit non-stationary substitution models using maximum likelihood, comparing the high- N e clade of rode...

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Literature Corpus work: b86abf9d-e37f-5d85-be43-3dedf36fcdf4
DOI: 10.1101/2023.02.01.526552

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