Article
A universal trend of amino acid gain and loss in protein evolution.
Nature - 10 Feb 2005
Jordan I King, Kondrashov Fyodor A, Adzhubei Ivan A, Wolf Yuri I, Koonin Eugene V, Kondrashov Alexey S, Sunyaev Shamil
Abstract excerpt
Amino acid composition of proteins varies substantially between taxa and, thus, can evolve. For example, proteins from organisms with (G + C)-rich (or (A + T)-rich) genomes contain more (or fewer) amino acids encoded by (G + C)-rich codons. However, no universal trends in ongoing changes of amino acid frequencies have been reported. We compared sets of orthologous proteins encoded by triplets of closely related...
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