Article

Estimating the selection pressure and evolutionary rate of proteins on the non-neutral hypothesis of synonymous mutations

2024-04-16

Abstract excerpt

The Nonsynonymous/Synonymous substitution rate ratio (Ka/Ks) is a commonly used metric to estimate the selection pressure and evolutionary rate of proteins in comparative genomics, which plays critical roles in molecular evolution in both biology and medicine. A fundamental assumption of Ka/Ks is that synonymous mutations are evolutionarily neutral and not subject to natural selection as they do not alter protein...

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Literature Corpus work: 63c0d195-082d-5b78-a558-f0a4e3b76931
DOI: 10.1101/2024.04.14.589335

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