Article
A Molecular Evolutionary Reference for the Human Variome.
Molecular biology and evolution - 1 Jan 2016
Liu Li, Tamura Koichiro, Sanderford Maxwell, Gray Vanessa E, Kumar Sudhir
Abstract excerpt
Widespread sequencing efforts are revealing unprecedented amount of genomic variation in populations. Such information is routinely used to derive consensus reference sequences and to infer positions subject to natural selection. Here, we present a new molecular evolutionary method for estimating neutral evolutionary probabilities (EPs) of each amino acid, or nucleotide state at a genomic position without using...
Topics
- Adaptation, Biological
- Disease
- Evolution, Molecular
- Genetic Variation
- Genome
- Genomics
- Humans
- Mutation
- Phylogeny