Article
Positive selection at sites of multiple amino acid replacements since rat-mouse divergence.
Nature - 3 Jun 2004
Bazykin Georgii A, Kondrashov Fyodor A, Ogurtsov Aleksey Y, Sunyaev Shamil, Kondrashov Alexey S
Abstract excerpt
New alleles become fixed owing to random drift of nearly neutral mutations or to positive selection of substantially advantageous mutations. After decades of debate, the fraction of fixations driven by selection remains uncertain. Within 9,390 genes, we analysed 28,196 codons at which rat and mouse differ from each other at two nucleotide sites and 1,982 codons with three differences. At codons where rat-mouse...
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