Biophysical Models of Protein Evolution: Understanding the Patterns of Evolutionary Sequence Divergence.

Abstract excerpt

For decades, rates of protein evolution have been interpreted in terms of the vague concept of functional importance. Slowly evolving proteins or sites within proteins were assumed to be more functionally important and thus subject to stronger selection pressure. More recently, biophysical models of protein evolution, which combine evolutionary theory with protein biophysics, have completely revolutionized our...

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