Article
Widespread positive selection in synonymous sites of mammalian genes.
Molecular biology and evolution - 1 Aug 2007
Resch Alissa M, Carmel Liran, Mariño-Ramírez Leonardo, Ogurtsov Aleksey Y, Shabalina Svetlana A, Rogozin Igor B, Koonin Eugene V
Abstract excerpt
Evolution of protein sequences is largely governed by purifying selection, with a small fraction of proteins evolving under positive selection. The evolution at synonymous positions in protein-coding genes is not nearly as well understood, with the extent and types of selection remaining, largely, unclear. A statistical test to identify purifying and positive selection at synonymous sites in protein-coding genes...
Topics
- Animals
- Evolution, Molecular
- Exons
- Gene Expression Profiling
- Introns
- Mice
- Mutation
- Polymorphism, Single Nucleotide
- RNA Stability
- Rats
- Selection, Genetic