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Article

Widespread positive selection in synonymous sites of mammalian genes.

Molecular biology and evolution - 1 Aug 2007

Resch Alissa M, Carmel Liran, Mariño-Ramírez Leonardo, Ogurtsov Aleksey Y, Shabalina Svetlana A, Rogozin Igor B, Koonin Eugene V

Abstract excerpt

Evolution of protein sequences is largely governed by purifying selection, with a small fraction of proteins evolving under positive selection. The evolution at synonymous positions in protein-coding genes is not nearly as well understood, with the extent and types of selection remaining, largely, unclear. A statistical test to identify purifying and positive selection at synonymous sites in protein-coding genes...

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Identifiers

PMID: 17522087
DOI: 10.1093/molbev/msm100
PMCID: PMC2632937

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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