Article

Dopaminergic Neurodegeneration Induced by Parkinson’s Disease-Linked G2019S LRRK2 is Dependent on Kinase and GTPase Activity

2019-12-18

Abstract excerpt

<h4> A bstract </h4> Mutations in the leucine-rich repeat kinase 2 ( LRRK2 ) gene cause late-onset, autosomal dominant familial Parkinson’s disease (PD) and represent the most common known cause of PD. LRRK2 can function as both a protein kinase and GTPase and PD-linked mutations are known to influence both of these enzymatic activities. While PD-linked LRRK2 mutations can commonly induce neuronal damage and...

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Literature Corpus work: 6bbdcc2a-1767-54af-b82c-0d3f446af231
DOI: 10.1101/2019.12.17.879759

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