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Article

Robust kinase- and age-dependent dopaminergic and norepinephrine neurodegeneration in LRRK2 G2019S transgenic mice.

Proceedings of the National Academy of Sciences of the United States of America - 13 Feb 2018

Xiong Yulan, Neifert Stewart, Karuppagounder Senthilkumar S, Liu Qinfang, Stankowski Jeannette N, Lee Byoung Dae, Ko Han Seok, Lee Yunjong, Grima Jonathan C, Mao Xiaobo, Jiang Haisong, Kang Sung-Ung, Swing Deborah A, Iacovitti Lorraine, Tessarollo Lino, Dawson Ted M, Dawson Valina L

Abstract excerpt

Mutations in LRRK2 are known to be the most common genetic cause of sporadic and familial Parkinson's disease (PD). Multiple lines of LRRK2 transgenic or knockin mice have been developed, yet none exhibit substantial dopamine (DA)-neuron degeneration. Here we develop human tyrosine hydroxylase (TH) promoter-controlled tetracycline-sensitive LRRK2 G2019S (GS) and LRRK2 G2019S kinase-dead (GS/DA) transgenic mice...

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Identifiers

PMID: 29386392
DOI: 10.1073/pnas.1712648115
PMCID: PMC5816154

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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