Article
Enhanced striatal dopamine transmission and motor performance with LRRK2 overexpression in mice is eliminated by familial Parkinson's disease mutation G2019S.
The Journal of neuroscience : the official journal of the Society for Neuroscience - 3 Feb 2010
Li Xianting, Patel Jyoti C, Wang Jing, Avshalumov Marat V, Nicholson Charles, Buxbaum Joseph D, Elder Gregory A, Rice Margaret E, Yue Zhenyu
Abstract excerpt
PARK8/LRRK2 (leucine-rich repeat kinase 2) was recently identified as a causative gene for autosomal dominant Parkinson's disease (PD), with LRRK2 mutation G2019S linked to the most frequent familial form of PD. Emerging in vitro evidence indicates that aberrant enzymatic activity of LRRK2 protein carrying this mutation can cause neurotoxicity. However, the physiological and pathophysiological functions of LRRK2...
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