Article
A rat model of progressive nigral neurodegeneration induced by the Parkinson's disease-associated G2019S mutation in LRRK2.
The Journal of neuroscience : the official journal of the Society for Neuroscience - 19 Jan 2011
Dusonchet Julien, Kochubey Olexiy, Stafa Klodjan, Young Samuel M, Zufferey Romain, Moore Darren J, Schneider Bernard L, Aebischer Patrick
Abstract excerpt
The G2019S mutation in the leucine-rich repeat kinase 2 (LRRK2) gene is the most common genetic cause of Parkinson's disease (PD), accounting for a significant proportion of both autosomal dominant familial and sporadic PD cases. Our aim in the present study is to generate a mammalian model of mutant G2019S LRRK2 pathogenesis, which reproduces the robust nigral neurodegeneration characteristic of PD. We developed...
Topics
- Analysis of Variance
- Animals
- Blotting, Western
- Brain
- Cell Count
- Disease Models, Animal
- Dopamine
- Female
- Immunohistochemistry
- Leucine-Rich Repeat Serine-Threonine Protein Kinase-2