Article
Overexpression of Parkinson's Disease-Associated Mutation LRRK2 G2019S in Mouse Forebrain Induces Behavioral Deficits and α-Synuclein Pathology.
eNeuro - 1 Jan 2000
Xiong Yulan, Neifert Stewart, Karuppagounder Senthilkumar S, Stankowski Jeannette N, Lee Byoung Dae, Grima Jonathan C, Chen Guanxing, Ko Han Seok, Lee Yunjong, Swing Debbie, Tessarollo Lino, Dawson Ted M, Dawson Valina L
Abstract excerpt
Mutations in the leucine-rich repeat kinase 2 (LRRK2) gene have been identified as an unambiguous cause of late-onset, autosomal-dominant familial Parkinson's disease (PD) and LRRK2 mutations are the strongest genetic risk factor for sporadic PD known to date. A number of transgenic mice expressing wild-type or mutant LRRK2 have been described with varying degrees of LRRK2-related abnormalities and modest...
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