Article

LRRK2 kinase inhibition reverses G2019S mutation-dependent effects on tau pathology spread

2023-10-06

Abstract excerpt

<h4>ABSTRACT</h4> Mutations in leucine-rich repeat kinase 2 (LRRK2) are the most common cause of familial Parkinson’s disease (PD). These mutations elevate LRRK2 kinase activity, making LRRK2 kinase inhibitors an attractive therapeutic target. LRRK2 kinase activity has been consistently linked to specific cell signaling pathways, mostly related to organelle trafficking and homeostasis, but its relationship to PD...

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Literature Corpus work: 21dac9e9-3592-529b-ad7e-00ea5e5ef63e
DOI: 10.1101/2023.10.06.561190

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