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Exploring LRRK2-dependent Mechanisms in Parkinson's Disease Therapy.

CNS & neurological disorders drug targets - 1 Jan 2025

Sharma Veerta, Sharma Shiwali, Singh Shareen, Singh Thakur Gurjeet

Abstract excerpt

Parkinson's disease (PD) is the second most common progressive neurodegenerative disease worldwide and presents as a progressive motor disorder. Gene mutations play a pivotal role in the degeneration of dopaminergic neurons in the substantia nigra region. Mutations in the Leucine rich repeat kinase 2 (LRRK2) gene have been identified as one of the most common genetic causes of PD. LRRK2 is a multi-functional...

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PMID: 40231505
DOI: 10.2174/0118715273377507250320035243

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