Article
Dopaminergic neurodegeneration induced by Parkinson's disease-linked G2019S LRRK2 is dependent on kinase and GTPase activity.
Proceedings of the National Academy of Sciences of the United States of America - 21 Jul 2020
Nguyen An Phu Tran, Tsika Elpida, Kelly Kaela, Levine Nathan, Chen Xi, West Andrew B, Boularand Sylviane, Barneoud Pascal, Moore Darren J
Abstract excerpt
Mutations in leucine-rich repeat kinase 2 (LRRK2) are the most common cause of late-onset, autosomal-dominant familial Parkinson's disease (PD). LRRK2 functions as both a kinase and GTPase, and PD-linked mutations are known to influence both enzymatic activities. While PD-linked LRRK2 mutations can commonly induce neuronal damage in culture models, the mechanisms underlying these pathogenic effects remain...
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