Article

UcTCRp: a TCRβ-based framework for quantitative MAIT- and iNKT-associated repertoire-state profiling

2026-05-28

Abstract excerpt

MAIT and iNKT cells are conventionally identified using invariant or semi-invariant TCRα chains, antigen-loaded tetramers, or transcriptomic phenotypes. These requirements limit their detection in public and clinical immune-repertoire datasets that contain only TCRβ sequences. Here we present UcTCRp, a TCRβ-only framework for profiling MAIT- and iNKT-associated repertoire states in bulk immune repertoires. UcTCRp...

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Literature Corpus work: 6bb3651f-fb40-5e21-8116-ff800714508c
DOI: 10.64898/2026.05.25.727598

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