Article

Discovery of rare antigen-specific TCRs via replicate profiling

2025-10-03

Abstract excerpt

Development of effective vaccines and targeted immunotherapies for cancer, autoimmunity, allergy, and infectious diseases requires comprehensive understanding of functionality and antigenic specificity of involved T cell clones. A major technical challenge remains the high-throughput identification of antigen-specific T cells. Here, we present a rapid cost-efficient TCR discovery assay starting from PBMC that enab...

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Literature Corpus work: a10f42cf-d7c1-597c-9d53-6048267432da
DOI: 10.1101/2025.09.30.675572

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