Article

Cross-tissue immune cell analysis reveals tissue-specific adaptations and clonal architecture in humans

2021-04-28

Abstract excerpt

Despite their crucial role in health and disease, our knowledge of immune cells within human tissues remains limited. Here, we surveyed the immune compartment of 15 tissues of six deceased adult donors by single-cell RNA sequencing and paired VDJ sequencing. To systematically resolve immune cell heterogeneity across tissues, we developed CellTypist, a machine learning tool for rapid and precise cell type annotatio...

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Literature Corpus work: 6b80d4a9-ade6-51b4-9f5d-b010bd68a1dc
DOI: 10.1101/2021.04.28.441762

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