Article

Peptide Driven Identification of TCRs (PDI-TCR) reveals dynamics and phenotypes of CD4 T cells in tuberculosis

2025-05-11

Abstract excerpt

Assigning antigen specificity to T cell receptor (TCR) sequences is challenging due to the TCR repertoire’s diversity and the complexity of TCR:antigen recognition. We developed the P eptide- D riven I dentification of TCR s (PDI-TCR) assay that combines in vitro expansion of cells with peptide pools, bulk TCR sequencing, and statistical analysis to identify antigen-specific TCRs from human blood. A key featu...

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Literature Corpus work: 3fc6e1b8-dec2-5842-a799-d9e4c353e92a
DOI: 10.1101/2025.05.06.652535

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