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<i>FKS1</i> is required for <i>Cryptococcus neoformans</i> fitness <i>in vivo</i> : application of copper-regulated gene expression to mouse models of cryptococcosis

2022-03-25

Abstract excerpt

There is an urgent need for new antifungals to treat cryptococcal meningoencephalitis, a leading cause of mortality in people living with HIV/AIDS. An important aspect of antifungal drug development is the validation of targets to determine whether they are required for the survival of the organism in animal models of disease. In Cryptococcus neoformans , a copper-regulated promoter (pCTR4-2) has been used to mod...

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Literature Corpus work
6b985d71-dea1-5190-94ef-96c129d6082d
DOI
10.1101/2022.03.24.485727
Open publication

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<i>FKS1</i> is required for <i>Cryptococcus neoformans</i> fitness <i>in vivo</i> : application of copper-regulated gene expression to mouse models of cryptococcosisDOI 10.1101/2022.03.24.485727
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