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Article

Genome‐wide analysis of the regulation of Cu metabolism in Cryptococcus neoformans

2 Apr 2018

Abstract excerpt

Summary The ability of the human fungal pathogen Cryptococcus neoformans to adapt to variable copper (Cu) environments within the host is key for successful dissemination and colonization. During pulmonary infection, host alveolar macrophages compartmentalize Cu into the phagosome and C. neoformans Cu‐detoxifying metallothioneins, MT1 and MT2, are required for survival of the pathogen. In contrast, during brain...

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PMID: 29608794
DOI: 10.1111/mmi.13960

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