Article
A copper hyperaccumulation phenotype correlates with pathogenesis in Cryptococcus neoformans.
Metallomics : integrated biometal science - 1 Apr 2013
Raja Meera R, Waterman Scott R, Qiu Jin, Bleher Reiner, Williamson Peter R, O'Halloran Thomas V
Abstract excerpt
Cryptococcus neoformans is a major human pathogen and a cause of meningoencephalitis in immunocompromised patients. Many factors contribute to the extraordinary survivability and pathogenicity of this fungus in humans, including copper homeostasis pathways. Previous work has shown that deletion of the copper-dependent regulator Cuf1 results in decreased virulence and dissemination in brain infection, suggesting...
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