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FKS1 Is Required for Cryptococcus neoformans Fitness In Vivo : Application of Copper-Regulated Gene Expression to Mouse Models of Cryptococcosis

4 May 2022

Abstract excerpt

Conditional expression systems are widely used to genetically validate antifungal drug targets in mouse models of infection. Copper-regulated expression using the promoter of the CTR4 gene has been sporadically used for this purpose in C. neoformans .

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Identifiers

PMID: 35506343
DOI: 10.1128/msphere.00163-22

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FKS1 Is Required for Cryptococcus neoformans Fitness In Vivo : Application of Copper-Regulated Gene Expression to Mouse Models of CryptococcosisPMID 35506343Read ↗

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