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Genetic analysis of Hsp90 function in Cryptococcus neoformans highlights key roles in stress tolerance and virulence

9 Oct 2021

Abstract excerpt

The opportunistic human fungal pathogen Cryptococcus neoformans has tremendous impact on global health, causing 181,000 deaths annually. Current treatment options are limited, and the frequent development of drug resistance exacerbates the challenge of managing invasive cryptococcal infections. In diverse fungal pathogens, the essential molecular chaperone Hsp90 governs fungal survival, drug resistance, and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 34849848
DOI: 10.1093/genetics/iyab164

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