Back to search

Article

A cysteine-rich domain of the <i>Cryptococcus neoformans</i> Cuf1 transcription factor is required for high copper stress sensing and fungal virulence

2024-12-13

Abstract excerpt

The ability to sense, import and detoxify copper (Cu) has been shown to be crucial for microbial pathogens to survive within an infected host. Previous studies conducted with the opportunistic human fungal pathogen Cryptococcus neoformans ( Cn ) have revealed two extreme Cu environments encountered during infection: a high Cu environment within the lung and a low Cu environment within the brain. However, how Cn...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
2fb143de-7d04-5f45-90c3-ddb7f9a1121a
DOI
10.1101/2024.12.13.628380
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
A cysteine-rich domain of the <i>Cryptococcus neoformans</i> Cuf1 transcription factor is required for high copper stress sensing and fungal virulenceDOI 10.1101/2024.12.13.628380
The copper regulon of the human fungal pathogen<i>Cryptococcus neoformans</i>H99Semantic proximity
A copper hyperaccumulation phenotype correlates with pathogenesis in Cryptococcus neoformans.Semantic proximity
Genome‐wide analysis of the regulation of Cu metabolism in Cryptococcus neoformansSemantic proximity
Role of a CUF1/CTR4 copper regulatory axis in the virulence of Cryptococcus neoformansSemantic proximity
Transcription factor–driven alternative localization of Cryptococcus neoformans superoxide dismutaseSemantic proximity
A fungal lytic polysaccharide monooxygenase is required for cell wall integrity, thermotolerance, and virulence of the fungal human pathogen <i>Cryptococcus neoformans</i>Semantic proximity
Adaptive changes in the fungal cell wall mediate copper homeostasisSemantic proximity
Copper at the Fungal Pathogen-Host AxisSemantic proximity
Evolution of the pathogenic mold Aspergillus fumigatus on high copper levels identifies novel resistance genes.Semantic proximity
Reciprocal functions of Cryptococcus neoformans copper homeostasis machinery during pulmonary infection and meningoencephalitisSemantic proximity
The ZIP family zinc transporters support the virulence of<i>Cryptococcus neoformans</i>Semantic proximity
Transcriptome analysis uncovers a link between copper metabolism, and both fungal fitness and antifungal sensitivity in the opportunistic yeast <i>Candida albicans</i>Semantic proximity
Select a neighboring publication to make it the new centre.