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Article

Role of a CUF1/CTR4 copper regulatory axis in the virulence of Cryptococcus neoformans

8 Feb 2007

Abstract excerpt

The study of regulatory networks in human pathogens such as Cryptococcus neoformans provides insights into host-pathogen interactions that may allow for correlation of gene expression patterns with clinical outcomes. In the present study, deletion of the cryptococcal copper-dependent transcription factor 1 (Cuf1) led to defects in growth and virulence factor expression in low copper conditions. In mouse models,...

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PMID: 17290306
DOI: 10.1172/jci30006

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Related research

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Role of a CUF1/CTR4 copper regulatory axis in the virulence of Cryptococcus neoformansPMID 17290306Read ↗

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An efficiently regulated promoter system for Cryptococcus neoformans utilizing the CTR4 promoterSemantic proximity Read ↗

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Transcriptome Analysis Uncovers a Link Between Copper Metabolism, and Both Fungal Fitness and Antifungal Sensitivity in the Opportunistic Yeast Candida albicansSemantic proximity Read ↗

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