Article

Mendelian randomization confirms the role of Y-chromosome loss in Alzheimer’s Disease etiopathogenesis in males

2022-07-22

Abstract excerpt

<h4>ABSTRACT</h4> Mosaic loss of chromosome Y (mLOY) is a common ageing-related somatic event occurring exclusively in men and has been previously associated with Alzheimer’s disease (AD). However, mLOY estimation from genotype microarray data only reflects the mLOY degree of subjects at the moment of DNA sampling. Therefore, mLOY phenotype associations with AD can be severely age-confounded in the context of geno...

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Literature Corpus work: 6b927081-47f1-58a6-bbf2-0b27d2edbfde
DOI: 10.1101/2022.07.20.22277657

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