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Article

Y chromosome mosaicism is associated with age-related macular degeneration

29 Aug 2018

Abstract excerpt

Age-related macular degeneration (AMD) is the leading cause of blindness in industrialised countries, and thereby a major individual but also a socio-economic burden. Y chromosome loss in nucleated blood cells has been implicated in age-related diseases such as Alzheimer disease and was shown to be caused by increasing age, smoking and genetic factors. Mosaic loss of Y chromosome (mLOY) in peripheral blood was...

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PMID: 30158665
DOI: 10.1038/s41431-018-0238-8

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